Methods for Stem Cell Expansion and Differentiation
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United States of America Patent
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Issued Date -
Jul 3, 2008
app pub date -
May 3, 2005
filing date -
May 3, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention provides methods, culture media, and apparatus to produce useful amounts of specific cell populations ex vivo by the modulation of Opn and/or an active Opn fragment. The present invention provides ex vivo expanded populations of HSC for use in transplantation therapy and in clinical and research activities, such as drug screening, toxicity testing, and other research activities. Also provided are methods, devices and culture media are provided to inhibit Opn binding to HISC to promote the increased production of more differentiated cell populations.
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