Combination cancer therapy with a GST-activated anticancer compound and another anticancer therapy

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United States of America Patent

APP PUB NO 20080159980A1
SERIAL NO

11872659

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Abstract

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A method of combination cancer therapy in a mammal, especially a human, by administering a therapeutically effective amount of a GST-activated anticancer compound and a therapeutically effective amount of another anticancer therapy, that is, an anticancer therapy that is not a treatment with a GST- activated anticancer compound (including chemotherapy; molecular targeted therapy; biologic therapy; and radiotherapy, used as monotherapy or in combination). Pharmaceutical compositions, products, and kits for the method. The use of a GST-activated anticancer compound in the manufacture of a medicament for the method. A method of potentiating an anticancer therapy in a mammal, especially a human, comprising administering a therapeutically effective amount of a GST-activated anticancer compound to the mammal being treated with the anticancer therapy. The use of a GST-activated anticancer compound in the manufacture of a medicament for the method. The GST-activated anticancer compound is preferably a compound of U.S. Pat. No. 5,556,942, and more preferably TLK286, especially as the hydrochloride salt.

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Patent Owner(s)

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TELIK INC750-H GATEWAY BOULEVARD SAN FRANCISCO CA 94080

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brown, Gail L Woodside, CA 13 32
Keck, James G Redwood City, CA 7 49
Schow, Steven R Redwood City, CA 46 509
Xu, Hua Sunnyvale, CA 547 9242

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