COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS
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United States of America Patent
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Issued Date -
Jun 26, 2008
app pub date -
Jun 12, 2007
filing date -
Jun 12, 2006
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Abstract
Embodiments of methods of using siRNAs targeting VEGF including an siRNA defined by SEQ ID NO: 77 and SEQ ID NO: 78 to stabilize visual acuity in a subject, to inhibit choroidal neovascularization lesions, to treat age-related macular degeneration, to treat diabetic macular edema, and to decrease foveal thickness in subjects are disclosed. Additionally, methods of treating age-related macular degeneration and diabetic macular edema by administering combinatorial therapy comprising an siRNA targeting VEGF and a non-siRNA VEGF antagonist are described.
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