POTENTIATION OF ANTIFUNGAL COMPOUNDS
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United States of America Patent
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Issued Date -
Jun 12, 2008
app pub date -
Aug 9, 2007
filing date -
Aug 11, 2006
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention provides methods and models for understanding how HDAC inhibitors interact with antifungal azole compounds to potentiate the activity of such compounds, using fungal strains which have selective knockouts of fungal HDAC genes. The invention further provides methods for testing antifungal agents for potential synergy with fungal HDAC inhibitors, and thus provides antifungal compound which are identified according to the methods of the invention, and methods for treatment of fungal infections using such compounds.
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International Classification(s)
- A01P:BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT....
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- A01N:PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLA....
- C12Q:MEASURING OR TESTING PROCESSES INVOLVING ENZYMES O....
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- A61P:THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDI....
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