SUSTAINED-RELEASE COMPOSITION AND METHOD OF USE THEREOF
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United States of America Patent
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Issued Date -
Jun 12, 2008
app pub date -
Sep 5, 2007
filing date -
Sep 8, 2006
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
A pharmaceutical composition comprising levodopa is provided that, when administered in a unit dosage amount of levodopa of about 100 to about 500 mg at a dosage interval of about 6 to about 24 hours, exhibits a sufficiently long release period and a sufficiently long residence time in the upper gastrointestinal tract to provide a trough concentration of levodopa in plasma of the subject that is not lower than a minimum threshold concentration below which adverse motor effects are observed in the subject. A method for treating Parkinson's disease in a subject is also provided, comprising orally administering such a composition to the subject in a unit dosage amount of levodopa of about 50 to about 1000 mg at a dosage interval of about 3 to about 24 hours.
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