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Abstract

Use of a compound which is (a) a benzodiazepine derivative of the formula (I) or an N-oxide thereof or (b) a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing an RSV infection wherein: --R.sup.1 represents C.sub.1-6 alkyl, aryl or heteroaryl; --R.sup.2 represents hydrogen or C.sub.1-6 alkyl; each R.sup.3 is the same or different and represents halogen, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.1-6 haloalkyl, C.sub.1-6 haloalkoxy, amino, mono(C.sub.1-6 alkyl)amino, di(C.sub.1-6alkyl)amino, vitro, cyano, --CO.sub.2R', --CONR'R'', --NH--CO--R', --S(O)R', --S(O).sub.2R', --NH--S(O).sub.2R', --S(O)NR'R'' or --S(O).sub.2NR'R'', wherein each R' and R'' is the same or different and represents hydrogen or C.sub.1-6 alkyl; n is from O to 3; R.sup.4 represents hydrogen or C.sub.1-6 alkyl; X represents --CO--, --CO--NR'--, --S(O)-- or --S(O).sub.2--, wherein R' is hydrogen or a C.sub.1-C.sub.6 alkyl group; and R.sup.5 represents a heteroaryl or heterocyclyl group which is substituted by a C1C6 hydroxyalkyl group or a --(C.sub.1-C.sub.4 alkyl)-X.sub.1--(C.sub.1-C.sub.4 alkyl)-X.sub.2--(C.sub.1-C.sub.4 alkyl} group, wherein X.sub.1 represents -0-, --S-- or --NR'--, wherein R' represents H or a C.sub.1-C.sub.4 alkyl group and X.sub.2 represents --CO--, --SO-- or --SO.sub.2--, or R.sub.5 represents -A.sub.1-Y-A.sub.2, wherein: -A.sub.1 is an aryl, heteroaryl, carbocyclyl or heterocyclyl group; 25 --Y represents a direct bond or a C.sub.1-C.sub.4 alkylene, --SO.sub.2--, --CO--, -0-, --S-- or --NR'-moiety, wherein R' is a C.sub.1-C.sub.6 alkyl group; and -A.sub.2 is an aryl, heteroaryl, carbocyclyl or heterocyclyl group.

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First Claim