Method for Ionically Cross-Linking Gellan Gum for Thin Film Applications and Medical Devices Produced Therefrom
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United States of America Patent
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Issued Date -
Jun 5, 2008
app pub date -
Nov 30, 2006
filing date -
Nov 30, 2006
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Abandoned
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Abstract
A method for producing ionically cross-linked gellan gum includes dissolving the material in a first liquid solution that includes a dissolving liquid. The first liquid solution is applied to a workpiece to form a polysaccharide-based coating on the workpiece. The coating is dried to remove a substantial portion of the dissolving liquid. Subsequent to drying, the coating is exposed to a second liquid solution that includes a compound that promotes ionic cross-linking of the coating. In the preferred embodiment, the dissolving liquid comprises water and possibly a polar solvent. The ionic cross-linking compound preferably comprises a divalent cation such as calcium (Ca.sup.2+), or possibly strontium (Sr.sup.2+), magnesium (Mg.sup.2+), barium (Ba.sup.2+), or other multivalent ions. Such a method forms a uniform ionically cross-linked film and/or coating for diverse applications, including medical devices such as implantable vascular grafts, stent-grafts and/or stents.
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