Method of improving bioavailability for non-sedating barbiturates
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United States of America Patent
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Issued Date -
Jun 5, 2008
app pub date -
Nov 14, 2007
filing date -
Nov 14, 2006
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Abandoned
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Abstract
Administration of 1,3-dimethoxymethyl-5,5-diphenylbarbituric acid and its related compounds with food increases the bioavailability of these compounds. The ratios (fasting/fed) for geometric mean AUC.sub.0-t were 35.6% (DMMDPB), 36.6% (MMMDPB) and 65.3% (DPB) and the geometric mean C.sub.max were 14.6% (DMMDPB), 31.9% (MMMDPB) and 62.9% (DPB). The cyclic ureides may be administered to a subject before or after ingestion of food within a defined time period.
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