Method for Identifying Inhibitors Using a Homology Model of Polo-Like Kinase 1

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United States of America Patent

APP PUB NO 20080132484A1
SERIAL NO

10579006

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Abstract

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The present invention relates to a homology model for PLK, and the use thereof in assays for the identification of small molecule PLK modulators. The invention further relates to PLK modulators identified by said assays, and their use in the treatment of PLK-related disorders such as proliferative disorders.

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Patent Owner(s)

Patent OwnerAddress
CYCLACEL LIMITEDLONDON EC2Y 5AU

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fischer, Peter Martin Angus, GB 36 295
McInnes, Campbell Dundee, GB 33 97
McLachlan, Janice Dundee, GB 5 52
Mezna, Mokdad Dundee, GB 3 18

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