ASSAYS FOR DETECTING NATIVE-STATE PROTEINS AND IDENTIFYING COMPOUNDS THAT MODULATE THE STABILITY OF NATIVE-STATE PROTEINS
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United States of America Patent
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Issued Date -
Jun 5, 2008
app pub date -
Sep 14, 2007
filing date -
Sep 15, 2006
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Abandoned
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Abstract
This invention relates to assays for detecting native-state proteins and to screening methods to identify compounds that modulate the stability of the native-state of proteins. Compounds identified by such screens can be used to treat diseases associated with protein misfolding, such as Alzheimer's Disease, familial amyloidotic polyneuropathies, and lysosomal storage diseases.
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