CERTAIN PYRIMIDINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
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United States of America Patent
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Issued Date -
May 29, 2008
app pub date -
Sep 11, 2007
filing date -
Sep 11, 2006
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Abstract
At least one chemical entity chosen from compounds of Formula 1 and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof, is described herein. Pharmaceutical compositions comprising at least one chemical entity of Formula 1, together with at least one pharmaceutically acceptable vehicle chosen from carriers adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.
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