Base Forming Drug-Layered Silicate Hybrid Containing Basic Polymer and its Synthesis Method
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United States of America Patent
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Issued Date -
May 22, 2008
app pub date -
Feb 21, 2006
filing date -
Feb 21, 2005
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Abandoned
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Abstract
Provided are a hybrid of a poorly soluble basic drug and a layered silicate, including a water-soluble basic polymer, and a method of preparing the same. The water-soluble basic polymer may be an aminoalkylmethacrylate copolymer (e.g., Eudragit E 100: a copolymer composed of 1:2:1 ratio of butyl methacrylate, (2,2-dimethylaminoethyl)methacrylate, and methyl methacrylate, Degussa) or polyvinylacetal diethylaminoacetate (AEA). In an oral formulation including the hybrid, a short-term dissolution of the poorly soluble drug can be increased to 90%, thereby increasing drug bioavailability.
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