6-ALKOXYALKYL ESTRADIOL DERIVATIVES AND METHODS OF USE
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United States of America Patent
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Issued Date -
May 22, 2008
app pub date -
Nov 29, 2007
filing date -
Sep 30, 2005
priority date (Note) -
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Abstract
A compound having the structure: wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.9 are independently hydrogen, C.sub.1 to C.sub.6 alkyl or substituted alkyl, halogen, sulfate or glucuronide moieties; the symbol represents either a single or a double bond and when the symbol is a double bond and forms a keto group at position 3 or 17, then no R.sub.7 or R.sub.6 is present, respectively; the symbol represent the presence or absence of a bond at position 10; and the symbol represents any type of bond regardless of the stereochemistry. The invention also embraces the enantiomers, other stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts of said compounds.
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