Stabilized Ornithine Transcarbamylase and Immunoassay Method for Ornithine Transcarbamylase Using the Same

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United States of America Patent

APP PUB NO 20080118931A1
SERIAL NO

11813053

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Abstract

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A method for stabilizing ornithine transcarbamylase (OTC) and a method of immunologically assaying OTC are provided. More specifically, the application provides a stabilized OTC solution having a pH of 5.5 to 7.0 as well as an immunological assay method of OTC including reacting an OTC antigen with an anti-OTC antibody at a pH of 7.5 to 10.5 or an immunological assay method of OTC including reacting an OTC antigen with an anti-OTC antibody at a pH of 6.5 to 10.5 in the presence of ProClin. According to the method of the present application, OTC level of a sample can be determined within a short period of time at high sensitivity. Thus, the method is useful for, for example, diagnosis of liver disease or follow-up after the onset of the disease.

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Patent Owner(s)

Patent OwnerAddress
YAMASA CORPORATIONCHOSHI-SHI CHIBA 288-0056

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Igarashi, Makoto Chiba, JP 114 1499
Murayama, Hiroshi Chiba, JP 80 849

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