Oncolytic adenoviral vectors encoding GM-CSF
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United States of America Patent
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app pub date -
Nov 5, 2007
filing date -
Aug 28, 2003
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Abstract
Selectively replicating oncolytic adenoviral vectors comprising an adenoviral packaging signal, a termination signal sequence, an E2F responsive promoter operably linked to an adenoviral coding region, a heterologous coding sequence encoding GM-CSF and a right ITR are provided. The oncolytic adenoviral vectors are useful for expressing GM-CSF in transduced cells and in methods for selectively killing neoplastic cells.
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