HEDGEHOG INHIBITOR ASSAY
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United States of America Patent
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Issued Date -
May 15, 2008
app pub date -
Jul 26, 2007
filing date -
Jan 31, 2005
priority date (Note) -
Abandoned
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Abstract
The present invention relates to the field of Hedgehog signalling, and more specifically to a cell-based assay system and methods for identifying inhibitors and/or antagonists of specific cellular events in said signalling pathway. The present invention hereby proposes a novel approach for identifying inhibitors and/or antagonists downstream of the signalling components Smoothened and Patched, e.g. at the Gli-level. The assay comprises cells lacking a functional Sufu protein, which according to the invention is a protein component of emerging importance in the Hedgehog signalling pathway.
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