Importance

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Abstract

Compounds of formula (I) are found to be active in inhibiting replication of flaviviridac Formula (I) wherein: X represents a direct bond or a moiety -L-NR--, wherein R is hydrogen or C.sub.1-C.sub.4 alkyl, and L represents a C.sub.1-C.sub.4alkylene, C.sub.6-C.sub.10 aryl or 5- to 10-membered heteroaryl moiety; either R.sub.1 and R.sub.2, together with the N atom to which they are attached, form a 5- to 10-membered heterocyclyl group or a 5- to 10-membered heteroaryl group, or R.sub.1 represents hydrogen, C.sub.6-C.sub.10 aryl, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 hydroxyalkyl and R.sub.2 represents C.sub.6-C.sub.10 aryl, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 hydroxyalkyl; and R.sub.3 represents a C.sub.6-C.sub.10 aryl, C.sub.3-C.sub.6 carbocyclyl, 5- to 10-membered heteroaryl or 5- to 10-membered heterocyclyl moiety, said aryl, carbocyclyl, heteroaryl and heterocyclyl groups being unsubstituted or substituted by 1, 2 or 3 substituents selected from halogen, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 alkoxy, C.sub.1-C.sub.4 haloalkyl, C.sub.1-C.sub.4 haloalkoxy, hydroxy, thiol, --NH.sub.2, C.sub.1-C.sub.4 hydroxyalkyl, C.sub.1-C.sub.4 thioalkyl and C.sub.1-C.sub.4aminoalkyl substituents.

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First Claim