Compositions and methods for enhanced mucosal delivery of interferon beta
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United States of America Patent
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Issued Date -
May 15, 2008
app pub date -
Dec 10, 2007
filing date -
Jun 28, 2002
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Abstract
Compositions and methods are provided for intranasal delivery of interferon-.beta. yielding improved pharmacokinetic and pharmacodynamic results. In certain aspects of the invention, the interferon-.beta. is delivered to the intranasal mucosa along with one or more intranasal delivery-enhancing agent(s) to yield substantially increased absorption and/or bioavailability of the interferon-.beta. and/or a substantially decreased time to maximal concentration of interferon-.beta. in a tissue of a subject as compared to controls where the interferon-.beta. is administered to the same intranasal site alone or formulated according to previously disclosed reports. The enhancement of intranasal delivery of interferon-.beta. according to the methods and compositions of the present invention allows for the effective pharmaceutical use of these agents to treat a variety of diseases and conditions in mammalian subjects.
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