Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
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United States of America Patent
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Issued Date -
May 15, 2008
app pub date -
Jan 11, 2008
filing date -
May 25, 2004
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Abandoned
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Abstract
A suspension formulation for therapeutic use includes a non-aqueous, hydrophobic vehicle exhibiting viscous fluid characteristics, a dry particle formulation comprising a biomolecule dispersed in the vehicle, and a surfactant incorporated in at least one of the vehicle and dry particle formulation. A dry particle formulation includes an interferon, a buffer, a surfactant, and one or more stabilizers selected from the group consisting of a carbohydrate, an antioxidant, and an amino acid.
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