Compounds and Their Use for Specific and Simultaneous Inhibition of Genes Involved In Diseases and Related Drugs
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United States of America Patent
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Issued Date -
May 8, 2008
app pub date -
Mar 18, 2004
filing date -
Mar 18, 2003
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Abstract
The invention relate to the use of a compound of formula A-B--C Wherein A is a DNA sequence-specific ligand capable of simultaneously and specifically recognizing a sequence common to genes of pathological interest; B is a linker arm, said linker arm being bound to the 3' end of A; C is a topoisomerase I posion; for the preparation of a drug for the treatment of a disease brought about by the expression of a gene and said gene is inhibited by the stabilized topoisomerase I-mediated DNA cleavage. Application, particularly, for the treatment of infective microorganism or virus, dismetabolic disease and autoimmune disease.
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