Development of Mammalian Genome Modification Technique Using Retrotransposon
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United States of America Patent
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Issued Date -
May 1, 2008
app pub date -
Nov 19, 2004
filing date -
Nov 21, 2003
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Abandoned
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Abstract
To comprehensively modify genome, it is intended to develop a transposition system of the copy and paste type which has an improved efficiency. This object has been achieved by the finding that an LTR retrotransposon is partly usable in a transposition system. Namely, a technique of efficiently transferring a foreign gene into a cell by using a transposon. More specifically speaking, a complete IPA element and a functional promoter sequence are found out. It is clarified that, without a combination of them, a retrotransposon cannot exert its function.
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