Small Interfering Rna and Pharmaceutical Composition for Treatment of Hepatitis B Comprising the Same
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United States of America Patent
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Issued Date -
Apr 24, 2008
app pub date -
Mar 9, 2006
filing date -
Mar 9, 2005
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Abstract
The present invention relates to RNA interference mediated inhibition of Hepatitis B virus (HBV) by short interfering RNA (siRNA) molecules. Specially, siRNAs of the present invention which are double-stranded RNAs concern directing the sequence-specific degradation of viral RNA in mammalian cells. Disclosed is a DNA vector encoding the RNA molecules and synthesized siRNA molecules as well as method of therapeutic treatment for inhibition of HBV gene expression and viral replication by the administration of RNA molecules of the present invention.
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