Methods for treating cancers and restenosis with P21

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United States of America Patent

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11981179

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Abstract

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The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G.sub.0/G.sub.1, alteration in morphology, and cell differentiation.

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Patent Owner(s)

Patent OwnerAddress
NABEL GARY JNot Provided

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nabel, Elizabeth G Ann Arbor, MI 26 958
Nabel, Gary J Ann Arbor, MI 131 4161
Yang, Zhi-yong Ann Arbor, MI 61 517

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