Novel Bone Metastasis Marker Peptide and Method of Diagnosing Bone Metastasis by Using the Same

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United States of America Patent

APP PUB NO 20080089889A1
SERIAL NO

11664001

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Abstract

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It is intended to provide: a peptide which shows an increase in the expression amount in the serum of a cancer patient with the passage of time before the onset of bone metastasis and after the onset of bone metastasis, is adsorbed by a weak cation exchanger at pH 6, and has an apparent molecular weight determined by mass spectrometry of about 5,800; a peptide fragment comprising the amino acid sequence corresponding to from 10- to 62-positions of the amino acid sequence of matured azurocidin; and a method of diagnosing bone metastasis in a cancer patient characterized by comprising detecting the expression of one of the above peptides in a biological sample originating in the cancer patient. According to this method, bone metastasis can be found and treated at the early stage.

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KURUME UNIVERSITY67 ASAHIMACHI KURUME-SHI FUKUOKA 8300011

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nagata, Kensei Fukuoka, JP 1 0
Sata, Michio Fukuoka, JP 7 96
Tsuru, Michiyo Fukuoka, JP 1 0

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