Therapeutic methods of using estrogen compositions
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United States of America Patent
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Issued Date -
Apr 10, 2008
app pub date -
Aug 10, 2006
filing date -
Aug 10, 2006
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Abandoned
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Abstract
A method for preventing or treating a catamenial migrainous disorder in a female subject comprises administering to a vulvovaginal surface of the subject a pharmaceutical composition that is bioadhesive thereto and comprises at least one estrogenic compound in an amount of about 50 .mu.g to about 1000 .mu.g estradiol equivalent per unit dose of the composition. A related method comprises administering to a vulvovaginal surface of the subject a pharmaceutical composition comprising at least one estrogenic compound, wherein upon administration of the composition to the vulvovaginal surface, a decline in serum estradiol concentration during a luteal phase of a menstrual cycle is moderated.
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