Method of Radiolabeling Formulations for Gamma Scintigraphy Assessment
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United States of America Patent
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Issued Date -
Mar 27, 2008
app pub date -
Jul 19, 2007
filing date -
Jul 19, 2006
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Abandoned
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Abstract
The present invention is directed to a novel method for producing a radiolabeled product for use in gamma scintigraphy, preferably for use with gastric retentive formulations. One aspect of the invention is the process which comprises adsorbing a suitable radionuclide onto a substrate, such as activated charcoal, and blending this nuclide/substrate product with an insoluble polymer; forming a melt blend of the polymer mix, cooling the melt blend to form a solid, and then breaking the solid into smaller particles. Suitably, the temperature of the melt blend is high enough to melt the polymer but not enough to degrade the polymeric material.
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