1,3-Diacylated, 26,27-Alkyl/Haloakyl Vitamin D3 Compounds and Methods of Use Thereof

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United States of America Patent

APP PUB NO 20080064668A1
SERIAL NO

10572995

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Abstract

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The invention provides (1,3)di-acylated vitamin D.sub.3 analogs of cholecalciferol, substituted at carbon (20) with methyl or cyclopropyl wherein carbon (16) is a single or double bond, and carbon (23) is a single, double, or triple bond. Various alkyl or haloalkyl substitutions are incorporated at carbon (25). The invention provides pharmaceutically acceptable esters, salts, and pro-drugs thereof. Methods for using the compounds to treat vitamin D.sub.3 associated states, and pharmaceutical compositions containing the compounds are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
BIOXELL S P AVIA OLGETTINA 58 1-20132 MILAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adorini, Luciano Milan, IT 23 97
Colli, Enrico Milan, IT 19 35
Penna, Giuseppe Cusano Milanino, IT 12 47
Uskokovic, Milan R Upper Montclair, NJ 74 985

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