Method Of Constructing Animal Model Suffereing From Left Ventricular Diastolic Disorder For Examining Heart Failure And Method Of Examining Remedy For Heart Failure Caused By Left Ventricular Diastolic Failure With The Use Of The Animal Model
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United States of America Patent
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Issued Date -
Feb 21, 2008
app pub date -
Apr 28, 2005
filing date -
Apr 28, 2004
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Abandoned
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Abstract
An animal model is provided which can be used for testing efficacy of a drug on left ventricular myocardial diastolic dysfunction, for example heart failure due to left ventricular diastolic failure. The present invention resides in a method for preparing an animal model with left ventricular diastolic dysfunction for testing a therapeutic agent for heart failure, the method comprising: intravenously injecting an aqueous solution of a water-soluble calcium salt into an anesthetized experimental small animal; and intravenously injecting an aqueous catecholamine solution into the animal, while continuing the intravenous injection of the aqueous solution of the water-soluble calcium salt, to raise left ventricular end-diastolic pressure of the heart of the animal to a level higher than normal left ventricular end-diastolic pressure, and it also resides in a method for preparing an animal model with left ventricular diastolic dysfunction for testing a therapeutic agent for heart failure due to left ventricular diastolic failure, the method comprising: intravenously injecting an aqueous norepinepfrine solution into the animal model prepared by the former method; measuring left ventricular end-diastolic pressure; and comparing the measured left ventricular end-diastolic pressure with normal left ventricular end-diastolic pressure of before the injection of the aqueous norepinephrine solution.
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