3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS
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United States of America Patent
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Issued Date -
Feb 21, 2008
app pub date -
Jul 5, 2007
filing date -
Jul 7, 2006
priority date (Note) -
Abandoned
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Abstract
Disclosed are novel cyclobutenedione Compounds 1 to 18 comprising a cyclobutenedione ring, a substituted phenyl ring, and a --CH(C.sub.2H.sub.5)-furan moiety. The phenyl ring and the --CH(C.sub.2H.sub.5)-furan moiety are each bound to the cyclobutenedione ring through a --NH-- moiety. Also disclosed are methods of treating chemokine mediated diseases (e.g., cancer, COPD, acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, and asthma) using the novel Compounds 1 to 18.
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