Composition Containing a Complex Comprising a Metal Ion and a Carboxylate Ligand Having Anti-Inflammatory Activity
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United States of America Patent
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Issued Date -
Feb 14, 2008
app pub date -
Mar 30, 2005
filing date -
Mar 30, 2004
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Abandoned
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Abstract
A pharmaceutical composition comprising a metal complex of a carboxylate having anti-inflammatory activity in a pharmaceutically acceptable carrier, wherein: (1) the composition has a colloidal structure, or forms a colloidal structure when administered to a human or animal, or is immiscible with water; (2) more than 80% of the total amount of the carboxylate having anti-inflammatory activity in the composition is present as part of a metal complex; and (3) less than 10% of the carboxylate having anti-inflammatory activity complexed with the metal dissociates from the metal over 12 months when the composition is stored in the absence of light at room temperature; but excluding compositions comprising a metal complex containing the ligand DMF. The invention also provides the use of the pharmaceutical composition in the treatment of inflammatory conditions in humans and animals.
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