USE OF ADENOSINE A1 ANTAGONISTS IN RADIOCONTRAST MEDIA INDUCED NEPHROPATHY

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United States of America Patent

APP PUB NO 20080027082A1
SERIAL NO

11765290

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Described herein are pharmaceutical combinations comprising a therapeutically effective amount of a first selective adenosine A1 antagonist and a first radiocontrast media. In one embodiment the selective adenosine A1 antagonist comprises 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-trans-cyclohexanol methanesulfonate and/or (4S)-4-hydroxy-1-(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-L-prolinamide methanesulfonate. Also described are the use of a first selective adenosine A1 antagonist in the treatment of radiocontrast media induced nephropathy. Furthermore, a kit comprising a therapeutically effective amount of a first selective adenosine A1 antagonist and a first radiocontrast media is also described herein.

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Patent Owner(s)

Patent OwnerAddress
SOLVAY PHARMACEUTICALS GMBHHANS-BOECKLER-ALLEE 20 D-30173 HANNOVER

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fischer, Yvan Barsinghausen, DE 15 47
Hocher, Berthold Hannover, DE 13 73
Witte, Klaus Hannover, DE 18 87
Ziegler, Dieter Hemmingen, DE 33 156

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