Test System for the Discovery of Substances for the Promotion of Neuraxonal Growth
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United States of America Patent
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Issued Date -
Jan 24, 2008
app pub date -
Mar 16, 2004
filing date -
Mar 21, 2003
priority date (Note) -
Abandoned
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Abstract
The invention relates to a method for identifying or testing active substances, which influence the growth and survival of nerve cells, wherein a cell is brought into contact with at least one substance and subsequently, within said cell, the mRNA of the .beta.-actin or the .beta.-actin protein alone or together with the SMN protein and/or a ribonucleic protein hnRNP, in particular the ribonucleic protein hnRNP-R and/or hnRNP-Q, are determined, and the determined amounts of said components are compared to the amounts of said components in a cell, which has not been brought into contact with the prospective active substance, to a test system for carrying-out said method and to uses of such test systems.
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