METHODS OF INCREASING PROTEIN EXPRESSION LEVELS
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United States of America Patent
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Issued Date -
Jan 17, 2008
app pub date -
Jul 16, 2007
filing date -
Nov 30, 2001
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Abstract
The present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline. Preferably, the substitution occurs within 15 amino acids, more preferably within 10 amino acids and most preferably within 5 amino acids of a cysteine amino acid residue. The present invention not only includes methods for polypeptides with proline substitutions, but also polynucleotides with codon substitutions for which a codon for any amino acid, except proline, is substituted for a codon encoding for proline.
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