COMPOSITIONS AND THERAPEUTIC METHODS OF USE
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United States of America Patent
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Issued Date -
Jan 3, 2008
app pub date -
Jun 28, 2007
filing date -
Jun 30, 2006
priority date (Note) -
Abandoned
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Abstract
A method for treating non-infectious inflammatory vulvovaginitis comprises administering to a vulvovaginal surface a pharmaceutical composition that comprises clindamycin in an amount of about 125 mg to about 400 mg per unit dose of the composition; wherein the composition is bioadhesive to the vulvovaginal surface, and upon application of the composition to the vulvovaginal surface the clindamycin is released over a period of about 3 hours to about 14 days. A related method comprises administering to a vulvovaginal surface a pharmaceutical composition comprising clindamycin or a pharmaceutically acceptable salt or ester thereof, wherein the composition has at least one non-lipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. A pharmaceutical composition comprises (a) clindamycin or a pharmaceutically acceptable salt or ester thereof in a clindamycin equivalent amount of about 2.5% to about 4% by weight; and (b) a phospholipid or non-ionic ester surfactant; wherein the composition is a vaginal cream having at least one non-lipoidal internal phase and at least one lipoidal external phase that is bioadhesive to a vaginal mucosal surface.
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