Zebrafish model for assessing gastrointestinal motility
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United States of America Patent
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Issued Date -
Dec 20, 2007
app pub date -
Mar 16, 2007
filing date -
Mar 16, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention has demonstrated the presence of the zebrafish KIT protein resulting from the expression of the kit gene in the zebrafish GI tract. As expression of the KIT protein is correlated with ICC in other species, the expression of the KIT protein in zebrafish indicates the presence of ICC in the zebrafish GI tract. ICC are required for spontaneous, coordinated contractions of GI smooth muscle. The present invention provides a zebrafish-based model system useful for elucidating the cellular and molecular mechanisms of gastrointestinal (GI) function and for identifying molecular targets for treating GI motility disorders in human.
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