Assay for efficacy of histone deacetylase inhibitors
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United States of America Patent
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Issued Date -
Dec 20, 2007
app pub date -
May 25, 2007
filing date -
May 26, 2006
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Abandoned
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Abstract
The invention provides methods for assessing the efficacy of histone deacetylase inhibitors using biomarkers which can be used in human clinical trials and which are more quantitative, easy to be used and more relevant to clinical outcome for PD monitoring than existing assays. The method according to the invention utilizes biomarkers from blood cells from patients treated with HDAC inhibitors which are easy to assay.
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