Compositions and Methods for Inducing Anti-Tumor Immunity
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United States of America Patent
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Issued Date -
Dec 13, 2007
app pub date -
Mar 25, 2005
filing date -
Mar 26, 2004
priority date (Note) -
Abandoned
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Abstract
Compositions and methods are provided for inducing anti-tumor immunity. More specifically, tumor cells and recombinant constructs are provided that express a cell surface CD83 polypeptide and/or a cell surface expressed antibody that specifically binds to an immune cell receptor, particularly an antibody that specifically binds to CD137. The invention also provides recombinant expression constructs comprising polynucleotides that encode a cell surface CD83 polypeptide, a cell surface expressed anti-immune cell receptor antibody, and/or at least one tumor antigen, and the related expressed products.
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