Peptidyl Arginine Deiminase Type IV Inhibitor
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United States of America Patent
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Issued Date -
Nov 29, 2007
app pub date -
Feb 3, 2005
filing date -
Feb 4, 2004
priority date (Note) -
Abandoned
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Abstract
A compound represented by the general formula (I) or a salt thereof is provided: wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, provided that at least one of R.sup.1, R.sup.2 and R.sup.3 does not represent a hydrogen atom; R.sup.4 represents an amino group which has a substituent; and R.sup.5 represents a carboxyl group which may have a substituent. Also provided is a peptidylarginine deiminase 4 inhibitor. The inhibitor can be used for the prevention and/or treatment of diseases associated with peptidylarginine deiminases (e.g., rheumatoid arthritis and multiple sclerosis).
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