SYNTHESIS, MODIFICATION AND REDUCTION OF PRIMARY STRUCTURE OF HYPOTENSIVE PEPTIDES PRESENT IN SCORPION VENOM FOR OPTIMIZING THEIR USE AS A HYPOTENSIVE MEDICAMENT
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Mar 19, 2007
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Jun 7, 2002
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Abstract
The present invention relates to synthetic and recombinant peptide primary structures including an amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 12, wherein the primary structure includes an +aa-Pro-Pro amino acid in which '+aa' is Lys, Arg, His or a modified amino acid having a positive charge at physiological pH. The present invention also relates to a pharmaceutical composition including at least one peptide having a primary structure as defined above.
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