FORMULATIONS FOR INTRACELLULAR DELIVERY dsRNA
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United States of America Patent
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Issued Date -
Nov 22, 2007
app pub date -
May 18, 2007
filing date -
May 18, 2006
priority date (Note) -
Abandoned
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Abstract
What is described is a composition for delivery of a RNA molecule to a cell, comprising: a double stranded RNA (dsRNA) molecule of about 15 to about 40 base pairs; and a cationic polymer peptide comprising at least two cysteine residues and at least one tryptophan residues with one or more repeats consisting of between about five to about 20 positively charged residues, a method for producing such composition, a method of using such composition to deliver dsRNA to a cell, and a method of using such composition to inhibit expression of a target gene.
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