Method for Producing Gene Transferred Denritic Cells
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United States of America Patent
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Issued Date -
Nov 22, 2007
app pub date -
Oct 29, 2004
filing date -
Nov 4, 2003
priority date (Note) -
Abandoned
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Abstract
The present invention provides a method for introducing a gene into a dendritic cell, which includes the step of contacting a minus-strand RNA virus with a dendritic cell. The present invention also provides a method for producing a gene transferred dendritic cell, which includes the step of contacting a minus-strand RNA virus with a dendritic cell. The present invention also provides gene transferred dendritic cells produced by such methods. Furthermore, the present invention provides a method for activating a dendritic cell, which includes the step of contacting a minus-strand RNA virus with a dendritic cell. The present invention enables efficient gene delivery into dendritic cells. Dendritic cells introduced with antigen gene or cytokine gene are useful as vaccine.
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