INHIBITORS OF INFLAMMATORY CYTOKINE TRANSCRIPTION DERIVED FROM HCMV PROTEIN IE2

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United States of America Patent

APP PUB NO 20070265201A1
SERIAL NO

11537534

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Abstract

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The present invention provides novel inhibitors of inflammation and methods for treating inflammation by using these inhibitors. More specifically, the present invention provides transcription inhibitors, i.e., peptide fragments derived from internal regions of the Cytomegalovirus (CMV) IE2 protein that can inhibit production of inflammatory cytokines, e.g., Interleukin 1 beta(IFN-1.beta.) and the methods for treating inflammatory diseases and CMV infection and related disorders, by using the IE2 fragments. An pharmaceutical composition comprising the transcription inhibitor are also provided.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION911 WILLIAM PITT UNION PITTSBURGH PA 15260

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Auron, Philip E Wexford, PA 12 240
Listman, James A Manlius, NY 1 0

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