Method of Regulating Heterologous Protein Expression Controlled by Salicylic Deratives in Micro-Organisms Associated with Higher Organisms

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United States of America Patent

APP PUB NO 20070264702A1
SERIAL NO

10581025

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Abstract

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The invention relates to a method which can be used to control the expression of heterologous proteins in micro-organisms using an expression system controlled by salicylate or derivatives. The genetic system can be used in attenuated pathogenic bacteria that can be induced once hosted by the eukaryotic cell by concentrations within the pharmacology safety range. The tropism of some bacteria for certain tissues or organs can be used to control the in-situ production of biomolecules for research purposes and as a system for the controlled release of biopharmaceuticals, e.g. in order to control the expression of anti-tumour proteins or antigens.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSIDAD PABLO DE OLAVIDE41013 SEVILLA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cebolla, Ramirez Angel Sevilla, ES 9 32
Sanchez-Palencia, Jose Luis Royo Sevilla, ES 2 2
Santurino, Eduardo Santero Sevilla, ES 2 2

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