Transdermal Antiemesis Delivery System, Method and Composition Therefor
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United States of America Patent
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Issued Date -
Nov 15, 2007
app pub date -
Sep 1, 2005
filing date -
Sep 1, 2004
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Abstract
A transdermal antiemesis system, preferably in the form of a drug-in-adhesive matrix patch, is disclosed comprising an effective antiemesis amount of a selective serotonin (5-HT.sub.3) receptor antagonist as an antiemetic incorporated in a skin adhesive composition containing at least one permeation enhancer and a water-insoluble pressure-sensitive adhesive. A preferred antiemetic is granisetron base. The transdermal antiemesis system of this invention provides controlled release of the active antiemetic ingredient from the skin-contacting adhesive formulation of a transderrnal patch, and maintains a sustained transdermal delivery of the antiemetic.
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