Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
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United States of America Patent
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Issued Date -
Nov 1, 2007
app pub date -
Apr 26, 2006
filing date -
Apr 26, 2006
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Abandoned
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Abstract
This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and R.sub.b is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.
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