ASSAYS AND PEPTIDE SUBSTRATE FOR DETERMINING AGGRECAN DEGRADING METALLO PROTEASE ACTIVITY

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United States of America Patent

SERIAL NO

11733232

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Abstract

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This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.

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Patent Owner(s)

Patent OwnerAddress
BRISTOL-MYERS SQUIBB PHARMA COMPANYPATENT DEPARTMENT P O BOX 4000 PRINCETON NJ 08543

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arner, Elizabeth C West Grove, PA 8 39
Copeland, Robert A Hockessin, DE 21 285
Davis, Gary L Lincoln University, DE 9 113
Liu, Ruiqin Hockessin, DE 7 35
Miller, Jeffrey A Lincoln University, PA 50 1495
Pratta, Michael Glassboro, NJ 11 118
Tortorella, Micky D Newark, DE 11 43

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