Method and Kit for Predicting Adverse Side Effects of Paclitaxel Therapy
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United States of America Patent
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Issued Date -
Oct 11, 2007
app pub date -
Nov 5, 2004
filing date -
Nov 5, 2003
priority date (Note) -
Abandoned
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Abstract
A method is disclosed for predicting the risk of the occurrence of granulocytopenia caused by paclitaxel therapy in a subject. The method of the present invention comprises identifying a genetic polymorphism in a gene isolated from the subject for five SNPs in CYP2C8 gene (IMS-JST111898 (SEQ ID NO: 1), IMS-JST105874 (SEQ ID NO: 2), IMS-JST082397 (SEQ ID NO: 3), IMS-JST071852 (SEQ ID NO: 4) and IMS-JST071853 (SEQ ID NO: 5)) and for five SNPs in BUB1b gene (IMS-JST074538 (SEQ ID NO: 6), IMS-JST079837 (SEQ ID NO: 7), IMS-JST044164 (SEQ ID NO: 8), IMS-JST 063023 (SEQ ID NO: 9) and IMS-JST042569 (SEQ ID NO: 10)). A kit comprising a reagent used in the method of the present invention is also disclosed.
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