3,6-Diazabicyclo[3.1.1]Heptane Derivatives with Analgesic Activity
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United States of America Patent
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Issued Date -
Sep 27, 2007
app pub date -
May 9, 2005
filing date -
May 12, 2004
priority date (Note) -
Abandoned
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Abstract
The invention relates to compounds of general formula (I), wherein R and R.sub.1, different from one another, are: a C.sub.2-C.sub.8 straight or branched acyl group; and a group of formula (II), wherein B and R.sub.2 are as defined in the description. The compounds (I) have higher central analgesic activity than morphine and are substantially free from the side effects of morphine or other central analgesics. The invention further relates to a process for the preparation of the compounds (I).
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