Microbial method for the 11beta hydroxylation of 9beta, 10alpha-steriods
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United States of America Patent
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Issued Date -
Sep 13, 2007
app pub date -
Jan 16, 2007
filing date -
Jan 18, 2006
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Abstract
Use of bacterial strains of the species Amycolatopsis mediterranei for microbial transformation of 9.beta.,10.alpha.-steroids of formula (I) to their corresponding 11.beta.-hydroxyl analogues, as well as specific strains of that species, a process for transforming 9.beta.,10.alpha.-steroids to their corresponding 11.beta.-hydroxyl derivatives using bacterials strains of the species Amycolatopsis mediterranei, and subsequent isolation of the 11.beta.-hydroxyl derivatives from the bacterial culture medium. The resulting 11.beta.-hydroxylated products are useful intermediates for preparing novel steroidal compounds with 9.beta.,10.alpha.-confirmation carrying different kinds of substituents in the 11.beta.-position.
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