MODIFIED ANNEXIN PROTEINS AND METHODS FOR THEIR USE IN ORGAN TRANSPLANTATION AND IN PREVENTION OF THROMBOSIS AND REPERFUSION INJURY

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United States of America Patent

APP PUB NO 20070207150A1
SERIAL NO

11613125

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Abstract

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Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage and to attenuate ischemia-reperfusion injury (IPI), are also provided. The modified annexins bind phosphatidylserine (PS) on cell surfaces, thereby preventing the assembly of the prothromkinase complex. The modified annexin decreases the binding of leukocytes and platelets during post-ischemic reperfusion, thereby restoring microvascular blood flow and decreasing organ damage.

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Patent Owner(s)

Patent OwnerAddress
ALAVITA PHARMACEUTICALS INC665 CLYDE AVENUE MOUNTAIN VIEW CA 94043

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allison, Anthony Belmont, CA 13 191

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